The need for effective government and regional planning has never been greater. This intensified demand is not for creating formal governance based on traditional regionalism. Rather the need is for flexible, adaptive governance, focused on specific issues, such as the Fourth Industrial Revolution and the changes anticipated in economics, education and planning, which are necessary for regional growth and survival. This is the starting point of the strategic plan for the Eastern Galilee and Kiryat Shmona. The plan consists of five chapters, which relate to the region as a composite of distinct industrial and economic specializations, and the product of its regional vision. The document provides planning guidance for the city of Kriyat Shmona. It suggests that a cooperation between the various municipalities in a framework of a unified region will deliver advantages of size and be a driving force for the economic development of the region. Cooperation between local authorities and investing their resources more productively may influence the local economy and even the national economy